研究院发表学术论文氢气对心脑血管疾病的防

氢气对心脑血管疾病的防治作用及机制的研究进展

薛俊莉，宋国华*，秦树存*

山东省高校动脉粥样硬化重点实验室，泰山医学院动脉粥样硬化研究所，医院，泰安

摘要:以往，氢气（H2）被认为是生理上的惰性气体。但是，近年来的研究表明，H2具有抗氧化、抗炎、抗凋亡等作用，在多种疾病模型中有显著的治疗效果，且在多项临床试验中也得到了较好的验证。心脑血管疾病是全世界致死率最高的疾病，严重威胁人类生命健康。本文就H2在心脑血管疾病中的生物医学效应及其可能的分子机制进行综述，以期全面介绍H2在该类疾病中的生物医学效应的最新研究进展，并为某些心脑血管疾病的临床治疗提供新思路。

关键词：氢气；心脑血管疾病；生物医学效应；分子机制

中图分类号：R

Researchadvancesonpreventiveandtherapeuticeffectsofhydrogenoncardiovascularandcerebrovasculardiseasesandunderlyingmechanisms

XUEJun-Li,SONGGuo-Hua*,QINShu-Cun*

KeyLaboratoryofAtherosclerosisinCollegesandUniversitiesofShandongProvince,InstituteofAtherosclerosisofTaishanMedicalUniversity,TaishanInstituteforHydrogenBiomedicalResearch,Taian,China

Abstract:Foralongtime,hydrogen(H2)hasbeenconsideredasaphysiologicalinertgas.However,recentstudieshavedemonstratedthatmolecularH2exertssignificanttherapeuticeffectsonvariousdiseasemodelsduetoitsantioxidative,anti-inflammatoryandanti-apoptoticcapabilities,whichhavealsobeenwellconfirmedinmanyclinicaltrials.Cardiovascularandcerebrovasculardiseases(CCVDs)aretheleadingcauseofdeathintheworld,constitutingaseriousthreattohumanlifeandpublichealth.Inthispaper,wereviewedthelatestresearchprogressofthebiomedicaleffectsofH2inCCVDsanditspossiblemolecularmechanisms,inthehopeofprovidingnewcluesforthetreatmentofsomeCCVDs.

Keywords:hydrogen;cardiovascularandcerebrovasculardiseases;biomedicaleffects;molecularmechanism

Researchfromthecorrespondingauthors’laboratorywassupportedbytheNationalNaturalScienceFoundationofChina(No.,)andtheTaishanScholarsFoundationofShandongProvince,China(No.ts,tsqn).

*Correspondingauthor.QINShu-Cun:Tel:+86--;E-mail:shucunqin